Senior Scientist Clinical Pharmacology and Pharmacometrics (Pharmacometrician)

Senior Scientist Clinical Pharmacology and Pharmacometrics (Pharmacometrician)

Do you have expertise in, and passion for Pharmacology and Pharmacometrics? Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicine.

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

The Senior Scientist position is a scientific job with responsibility for pharmacometrics (PMx) activities including population PK, PKPD, exposure-response, and drug-disease modelling in all clinical development phases. With support from more senior Pharmacometricians, Team Leads and the TA Head, the incumbent will be responsible for integrating and analysing internal (and external) data to support interpretation and decision making.

The individual will work to leverage foundational and cutting-edge pharmacometrics techniques, in combination with business domain knowledge, to develop and apply advanced models to generate business and scientific insights. The role will work within defined project scope and solutions aligned to established governance frameworks and policies.



Responsibilities:

Accountable for data integration, analysis, and reporting of PMx results at the study level

Accountable for executing state-of-the-art PMx techniques with direct value for the project

Contribute PMx activities to influence study designs and go/no go decisions

Contribute to regulatory documents and interactions (written)

Presentation of PMx results in internal and external forum

Contribute to internal initiatives to develop the pharmacometric discipline including its processes

Participation in peer review of ongoing activities, reports and presentations

Compliance with Good Clinical Practice (GCP) regulations as well as internal/external guidance’s

Requirements:

Demonstrated experiences in pharmacometrics, including PK, PKPD and/or statistics

Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling).

Ability to identify, develop and execute clinical pharmacometrics activities at a project level

Basic oral and written communication skills

Fluency in English (oral and written)

PhD degree preferred or equivalent (M.Sc./Pharm.D.) with relevant experience required

Training and experience with pharmacometrics PK/PD software (NonMem, R, Stan, Monolix, or similar)

Desirable:

Scientific publishing in the field on pharmacometrics

Early or late phase clinical development experience/awareness

Experience with concentration-QTc pharmacometrics analysis

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial -finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted 26-mar-2023

Closing Date 25-abr-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
AstraZeneca

Fecha de publicación: 28/03/2023