PhD position: Immunotherapy against leukemia (OPTI-CAR-T)
Offer Description
The “Development of the human lymphohematopoietic system” group, led by Marisa Toribio at the Centro de Biología Molecular Severo Ochoa (CBMSO), is looking for a highly motivated candidate to develop her/his thesis in their lab. They offer incorporation via a 4-year predoctoral contract (FPI programme) linked to the project “Overcoming current challenges of CAR-T cell immunotherapy for T-ALL leukemia with optimized CAR constructs (TRuCs) and universal, off-the-shelf, effector allogeneic T cells (OPTI-CAR-T)” (PID2022-138880OB-I00) funded by the Spanish Ministry of Science and Innovation (MICIN) and the State Research Agency (AEI).
Requirements:
Graduate in biomedical sciences or related areas, with a minimum of 300 ECTS through official university studies, with a minimum of 60 ECTS in master studies.
Academic record with an average grade over 8 (out of 10).
Experience in in vivo mouse models, cell culture, immunology and molecular biology will be valued.
Solid communication skills in English.
OPTI-CAR-T is aimed at investigating and validating independent, but complementary, molecular and cellular innovative strategies focusing on optimization of target recognition structures (chimeric antigen receptors, CARs) and effector T cells armed with them, which, in combination, are expected to overcome current challenges of CAR-T immunotherapy for T-cell acute lymphoblastic leukemia (T-ALL). The general goal is to optimize the expression and function of endogenously regulated TCR-fused CAR constructs (TRuCs) that target a surface molecule specifically expressed on T-ALL cells, in combination with the production of universal, allogeneic effector CAR-T cells (uCAR-T) to express them, as the foundations of a next generation, off-the-shelf, universal CAR-T immunotherapy for relapsed/refractory T-ALL that will be validated in preclinical assays.
Further information:
About the group:
About the CBMSO:
Requirements
Research Field Biological sciences Education Level Master Degree or equivalent
Skills/Qualifications
Requirements:
Graduate in biomedical sciences or related areas, with a minimum of 300 ECTS through official university studies, with a minimum of 60 ECTS in master studies.
Academic record with an average grade over 8 (out of 10).
Experience in in vivo mouse models, cell culture, immunology and molecular biology will be valued.
Solid communication skills in English.
Languages ENGLISH Level Excellent
Research Field Biological sciences Years of Research Experience 1 - 4
Internal Application form(s) needed
4-year predoctoral contract OPTI-CAR-T ML Toribio 2023.pdf
English
(362.42 KB - PDF)
Additional Information
Website for additional job details
Work Location(s)
Number of offers available 1 Company/Institute Centro de Biología Molecular Severo Ochoa Country Spain State/Province Madrid City Madrid Postal Code 28033 Street Nicolás Cabrera, 1
Where to apply E-mail
mtoribio@cbm.csic.es
Contact State/Province
Madrid City
Madrid Website
Street
Nicolás Cabrera 1 Postal Code
28049 E-Mail
mtoribio@cbm.csic.es
STATUS: EXPIRED
EURAXESS
Fecha de publicación: 30/07/2023
